Posted by yxibow on December 28, 2008, at 22:54:55
In reply to could nefazodone get any more peculiar?, posted by iforgotmypassword on December 28, 2008, at 17:39:22
> http://www.journals.elsevierhealth.com/periodicals/bps/article/PII000632239390310A/abstract
>
> "Nefazodone significantly increased plasma levels of prolactin (PRL) and raised oral temperature. There was also a trend towards an increase in plasma cortisol. These results are consistent with an acute facilitatory effect of some aspects of 5-HT neurotransmission, perhaps mediated through nefazodone's metabolism to its major metabolite, m-chlorophenylpiperazine (mCPP)."
>
> this may be wrong, i was under the impression that a 5-HT2a antagonistic mechanism would lower cortisol, so i am thinking either the mCPP metabolite much more significant than imagined, or the drug is much messier than it already looks. and prolactin...?
mCPP isn't quite as harmful as it has seemed to be unless you have a psychosis spectrum disorder.The "study" included only 8 people, which is just a journal note.
Nefazodone's main problem is still rare but present liver problems. Monitoring every so often is important-- Jay
poster:yxibow
thread:871201
URL: http://www.dr-bob.org/babble/20081223/msgs/871230.html