Posted by SLS on December 17, 2008, at 5:43:01
In reply to Re: Treatment Resistant (Refractory) Depression, posted by desolationrower on December 16, 2008, at 21:56:34
I understand that lithium is thought to directly inhibit the reuptake of glutamate, but I am still unclear as to how it can stabilize and limit glutamatergic excitation. I recall something involving NMDA receptors, but I don't know if lithium acts directly to change the conformation of the transporter molecule. What else does lithium do to influence glutamate activity? How might protein kinase-C inhibition affect glutamate?
Thanks.
- Scott
poster:SLS
thread:868231
URL: http://www.dr-bob.org/babble/20081214/msgs/869207.html