Posted by crittercuddler on December 16, 2008, at 3:31:48
In reply to Re: SSRI insomnia, restlessness, poor concentration, posted by desolationrower on December 15, 2008, at 23:56:18
How do 5HT2A antagonists sometimes worsen OCD? I remember reading that the atypical anti-psychotics can do that when used alone and not in conjunction with an SSRI (not sure how)... but I wasn't planning on using one alone.
That would be really lousy if that happened to me because I don't see any other options for me other than to try an augment an SSRI or a SNRI with an SARI, the TCA nortriptyline, or an atypical anti-psychotic in order to help the agitation, anxiety, insomnia, muscle jerks... etc.... and ALL of those have some kind of 5HT2A antagonism.
From what I read, the SARIs are the strongest 5HT2A antagonists (nefazodone and trazadone) and I after that I don't know where the atypicals (like Seroquel, Risperdal, or Zyprexa) and the TCA nortriptyline would fall into order at.
All the drugs I am left to work with (if I cut out SSRIs and SNRIs all together) have 5HT2A antagonism to some degree. Except Buproprion and I don't see that helping me by itself with major depression and OCD.
Ugh... I am so tired. My brain is fried. No more research or thinking about this tonight. I have been looking at this stuff so long my understanding is starting to regress because I am so exhausted.
I will let you all know how it goes at the doctor tomorrow.
Oh, btw, I made some suggestions to NewQuestions.... maybe you could swing by that thread to check them and see if they are right.
????? Thanks. :-)
poster:crittercuddler
thread:868434
URL: http://www.dr-bob.org/babble/20081214/msgs/869053.html