Posted by Tomatheus on December 14, 2008, at 4:03:14
In reply to MAOI plus Sam-E, posted by uncouth on December 13, 2008, at 17:40:46
uncouth,
I took SAMe with the Goldshield Parnate (U.K. version) for about three months before I became psychotic. The combo produced a nice antidepressant effect. It wasn't full remission, but I definitely felt more energized on the combo than I did when I was at my depressed baseline. What was also significant about my response to SAMe and Parnate was that the antidepressant benefits were actually consistent from one day to the next.
I found the best doses of Parnate and SAMe to be 20 mg and 150 mg, respectively. I took 20 mg of Parnate with 200 mg of SAMe for a while, but I felt too fatigued from the SAMe. Lowering the dose to 150 mg (which was a hassle because I had to cut the tablets in fourths and put the contents of them in enteric capsules) reduced my fatigue. At one point, I also tried taking 30 mg of Parnate with 150 mg of SAMe. I forget what happened, but somehow my response to the combo at that dose ended up being inferior to my response at 20 mg of Parnate and 150 mg of SAMe, so I ended up switching back to that dose.
I can't really say how Parnate and SAMe would mix at higher doses. While I was on the combo, I never went above 30 mg of Parnate and 400 mg of SAMe.
Tomatheus
poster:Tomatheus
thread:868565
URL: http://www.dr-bob.org/babble/20081214/msgs/868666.html