Posted by B2chica on December 11, 2008, at 13:28:14
In reply to phasic vs. tonic inhibitory currents/psych med, posted by B2chica on December 11, 2008, at 13:10:56
found a study re effects of vigabatrin (which inhibits GABA transaminase)
first Gabapentin increased a tonic inhibitory conductance.
next they found that High-affinity GABAa receptors (which generate the tonic current) may detect small increases in the 'ambient' concentration of neurotransmitter caused by gabapentin.So GABAa receptors were 'insensitive to the acute application of gabapentin, wheraes chronic treatment increased the amplitude of the tonic current threefold.'
the meds that come to mind are:
Depakote, Nardil (gaba increase -gaba transaminase inhibition
Topomax, gabaA receptor enhancement
and what about provigil since it is a GABA decrease?any input appreciated.
thanks
b2c.
poster:B2chica
thread:868093
URL: http://www.dr-bob.org/babble/20081204/msgs/868101.html