Posted by bulldog2 on December 4, 2008, at 11:27:38
It appears as if the tcas are more effective for major depression than the ssris. Your list seemed to affirm this from your subjective experiences.
Here are some of my theories.
1. They affect more neurotranmitters. Generally effect ne and se.
2. Their effect on se is not nearly as profound as the ssris.
3. It seems as if the marked elevation of se by the ssris eventually diminishes dopamine which probably has a negative effect on the mood and hormonal system.
4. Perhaps the tcas do not have as much negative impact on dopamine as the ssris. I believe dimished dopamine produces the apathy that many describe on ssris.
5. I remember my physician years ago was very skeptical about the new wonder ssris. Felt the huge elevation in serotonin could lead to problems.Do you have any theories Scott?
poster:bulldog2
thread:866651
URL: http://www.dr-bob.org/babble/20081204/msgs/866651.html