Posted by Phillipa on December 1, 2008, at 19:58:35
In reply to Re: Is the LDN making me anxious?? » Jimmyboy, posted by Phillipa on December 1, 2008, at 19:24:30
Intersting let me know what you think Love Phillipa ps used to be a runner no depression anxiety then.
History
Opioid neuropeptides were first discovered in 1975 by two independent groups of investigators.and Hans Kosterlitz of Scotland isolated from the brain of a pig what they called enkephalins (from the Greek εγκέφαλος, cerebrum).[5][6]
Around the same time in the calf brain, Rabi Simantov and Solomon H. Snyder of the United States found[7] what Eric Simon (who independently discovered opioid receptors in the brain) later termed "endorphin" by an abbreviation of "endogenous morphine", which literally means "morphine produced naturally in the body".[citation needed] Importantly, recent studies have demonstrated that diverse animal and human tissues are in fact capable of producing morphine itself, which is not a peptide.[8][9][edit] Mechanism of action
Beta-endorphin is released into the blood (from the pituitary gland) and into the spinal cord and brain from hypothalamic neurons. The beta-endorphin that is released into the blood cannot enter the brain in large quantities because of the blood-brain barrier. The physiological importance of the beta-endorphin that can be measured in the blood is far from clear: beta-endorphin is a cleavage product of pro-opiomelanocortin (POMC) which is also the precursor hormone for adrenocorticotrophic hormone (ACTH). The behavioural effects of beta-endorphin are exerted by its actions in the brain and spinal cord, and probably the hypothalamic neurons are the major source of beta-endorphin at these sites. In situations where the level of ACTH is increased (e.g. Addison disease), the level of endorphins also increases slightly.Beta-endorphin has the highest affinity for the μ1-opioid receptor, slightly lower affinity for the μ2- and δ-opioid receptors and low affinity for the κ1-opioid receptors. μ-receptors are the main receptor through which morphine acts. Classically, μ-receptors are presynaptic, and inhibit neurotransmitter release; through this mechanism, they inhibit the release of the inhibitory neurotransmitter GABA, and disinhibit the dopamine pathways, causing more dopamine to be released. By hijacking this process, exogenous opioids cause inappropriate dopamine release, and lead to aberrant synaptic plasticity, which causes addiction. Opioid receptors have many other and more important roles in the brain and periphery however, modulating pain, cardiac, gastric and vascular function as well as possibly panic and satiation, and receptors are often found at postsynaptic locations as well as presynaptically.
[edit] Activity
Scientists debate whether specific activities release measurable levels of endorphins. Much of the current data comes from animal models which may not be relevant to humans. The studies that do involve humans often measure endorphin plasma levels, which do not necessarily correlate with levels in the CNS. Other studies use a blanket opioid antagonist (usually naloxone) to indirectly measure the release of endorphins by observing the changes that occur when any endorphin activity that might be present is blocked.Capsaicin (the active chemical in red chili peppers) also has been shown to stimulate endorphin release.[10] Topical capsaicin has been used as a treatment for certain types of chronic pain.
[edit] Runner's high
Another widely publicized effect of endorphin production is the so-called "runner's high", which is said to occur when strenuous exercise takes a person over a threshold that activates endorphin production. Endorphins are released during long, continuous workouts, when the level of intensity is between moderate and high, and breathing is difficult. This also corresponds with the time that muscles use up their stored glycogen. Workouts that are most likely to produce endorphins include running, swimming, cross-country skiing, long distance rowing, bicycling, hockey, tennis, weight lifting, aerobics, or playing a sport such as soccer, basketball, rugby, lacrosse, or American football.However, some scientists question the mechanisms at work, their research possibly demonstrating the high comes from completing a challenge rather than as a result of exertion.[11] Studies in the early 1980s cast doubt on the relationship between endorphins and the runner's high for several reasons:
The first was that when an antagonist (pharmacological agent that blocks the action for the substance under study) was infused (e.g. naloxone) or ingested (naltrexone) the same changes in mood state occurred as when the person exercised with no blocker.
A study in 2003 by Georgia Tech found that runner's high might be caused by the release of another naturally produced chemical, Anandamide. Anandamide is similar to the active endocannabinoid anandamide,[12][13] The authors suggest that the body produces this chemical to deal with prolonged stress and pain from strenuous exercise, similar to the original theory involving endorphins. However, the release of anandamide was not reported with the cognitive effects of the runners high; this suggests that anandamide release may not be significantly related to runner's high.[13]In 2008, researchers in Germany reported that the myth of the runner's high was not a myth but was in fact true. Using PET scans combined with recently available chemicals that reveal endorphins in the brain, they were able to compare runners brains before and after a run.[14] The runners the researchers recruited were told that the opioid receptors in their brains were being studied, and did not realize that their endorphin levels were being studied in regard to the runner's high.
The participants were scanned and received psychological tests before and after a two-hour run. Data received from the study showed endorphins were produced during the exercise and were attaching themselves to areas of the brain associated with emotions (limbic and prefrontal areas).[15]
[edit] Acupuncture
In 1999, clinical researchers reported that inserting acupuncture needles into specific body points triggers the production of endorphins.[16][17] In another study, higher levels of endorphins were found in cerebrospinal fluid after patients underwent acupuncture.[18] In addition, naloxone appeared to block acupunctures pain-relieving effects. However, skeptics say that not all studies point to that conclusion,[19] and that in a trial of chronic pain patients, endorphins did not produce long-lasting relief. Endorphins may be released during low levels of pain and physical stimulation when it lasts over 30 minutes. Questions remain as to whether the prolonged low level of pain stimulation as in Capsaicin, acupuncture and running or physical activity alone are the threshold that activates endorphin release.
[edit] References
^
poster:Phillipa
thread:866062
URL: http://www.dr-bob.org/babble/20081123/msgs/866165.html