Posted by bleauberry on November 28, 2008, at 9:18:56
In reply to Seroquel Compliant, posted by dayandnight on November 27, 2008, at 13:59:41
I think Racer said it the best. It is either longterm serotonin potentiation, or it is poopout beginning to be noticeable. SSRI induced apathy is, I think, much more common than literature talks about. I think the reason may be that it usually shows up many months or even a couple years after starting the medication, and it shows up in such a gradual subtle fashion that you don't notice it until it is quite prominent. For a lot of us it shows up almost immediately or within a few weeks. It is a horrible life to be in depression, but it is also a very strange crippled life to be in a state of emotional numbness.
Seroquel could be at fault, but at 50mg I don't think it is blocking dopamine enough to do that. 20mg Lexapro on the other hand is very significant power.
So what to do? If Lex has you non-depressed, then the safest option would be to augment it with something specifically geared towards your symptoms. Such as Provigil, Ritalin, Dexedrine, Adderall, Wellbutrin, and possibly replace Seroquel with Abilify.
If Lex is not working well, however, then it might make more sense to ditch it completely, with a slow careful weaning strategy, and replace it with a different antidepressant.
poster:bleauberry
thread:865486
URL: http://www.dr-bob.org/babble/20081123/msgs/865565.html