Posted by bleauberry on November 26, 2008, at 14:00:38
In reply to Moclobemide + Escitalopram, posted by Medline on November 26, 2008, at 2:02:43
> I already used Moclobemide at 900-1200mg for 3 months two years ago, it didn't really help. I will try the experiment, but be extremely careful and I have a potent 5HT2A-antagonist at hand if things go wrong.
If you've already tried it like that, and it didn't work, I fail to understand why one would go there again, when there are dozens or hundreds of other combinations/permutations to visit that you haven't.
One thing with combinations/augmentations that seems to make them work the best is when they are different mechanisms. Moclobemide and SSRI really isn't a variety of mechanisms. It is all just increasing neutrotransmitter levels. Something like Prozac + Zyprexa is different, as one is increasing neuro levels, the other is boosting those increases even more across the entire board, and at the same time interrupting feedback loops and blocking side effects and redirecting where signals go and re-instructing genes what to do, and such. Or a SSRI+stimulant thing, or a SSRI+TCA thing (increasing neuros, but also blocking many receptors), or a SSRI+antipsychotic thing, on and on. Different mechanisms.
What is the 5HT2A antagonist you have?
poster:bleauberry
thread:865206
URL: http://www.dr-bob.org/babble/20081123/msgs/865373.html