Posted by Medline on November 26, 2008, at 13:48:44
In reply to Re: Zoloft +Wellbutrin - any success? » Treehugger, posted by llurpsienoodle on November 26, 2008, at 6:42:45
Combining Bupropion with SSRIs will increase levels of 5-HT, NE and DA. MAOIs like Parnate also "hit" this systems (and many others), but via a completely different mechanism and probably "harder" (AFAIK Bupropion is not a very strong DRI). Nardil also increases brain GABA levels as one of it's metabolites is a GABA-transaminase-inhibitor.
To make a long story short: Bupropion/SSRI-combos are no "MAOI-substitutes". Nevertheless this AD augmentation/combination-strategy can be a very effective one, also for partial- or non-responders to SSRIs. The prefered SSRI should be one with low interaction potential like Citalopram/Escitalopram/Sertraline as Bupropion interferes with the metabolism of many drugs including some SSRIs like eg. Paroxetine.
poster:Medline
thread:865173
URL: http://www.dr-bob.org/babble/20081123/msgs/865371.html