Posted by Marty on November 25, 2008, at 9:40:07
In reply to Re: Agomelatine how does it work?, posted by Cecilia on November 25, 2008, at 3:21:24
Hi Cecilia,Agomelatine 5-HT2c antagonism properties doesn't "increased serotonin level" but enhances the activity of frontocortical dopaminergic and adrenergic pathways. So SSRIs are mainly serotonergic and Agomelatine is dopaminergic/adrenergic/melatonergic. I say mainly because most of them have more properties than being serotonergic, exception being (Es)citalopram which is the most selective of the SSRIs. As example, Paroxetine (Paxil) as some DRI (Dopamine Reuptake Inhibition) properties and Prozac, which is famous for being the first blockbuster SSRI, is in fact an atypical SSRI because it has more significant 5-HT2c antagonism effect than a serotonin reuptake effect.
While you could very crudely emulate Agomelatine MT1/2 agonism with some Melatonin, I'm not aware of any supplement capable of 5-HT2c antagonism.
/\/\arty
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> Seems like the article just discussed this drug's serotonin effects plus melatonin. How does it differ from a SSRI plus melatonin (which you can buy over the counter)? Cecilia
poster:Marty
thread:864397
URL: http://www.dr-bob.org/babble/20081123/msgs/865170.html