Posted by SLS on November 24, 2008, at 6:20:46
In reply to Re: Abilify - What prevents you from taking 10-20mg? » SLS, posted by JadeKelly on November 24, 2008, at 1:50:09
> > I am curious as to what prevents people from taking 10-20mg of Abilify.
> >
> >
> > - Scott
>
> My son was a zombie on it. Paranoid. He was on higher dose for mania. What does 10mg Abilify do for you? If very small amount turned out to be excellent augment for say, Parnate, I wouldn't be adverse to trying it if I knew why.I am still amazed when two people react to the same drug in opposite ways.
I addressed questions regarding my experience with Abilify here:
http://www.dr-bob.org/babble/20081123/msgs/864879.html
I don't know at what dosage Abilify occupies enough postsynaptic dopamine D2 receptors so as to produce sufficient agonism to obtain an antidepressant effect. Perhaps it is this agonism that produces too much activation and agitation for some people. An alternate explanation is that the increase in DA release due to presynaptic blockade reverses the agonistic properties of Abilify postsynaptically. This might explain the sensations of numbness and cognitive slowing some people experience.
Maybe one needs to start right at 10-20mg to produce a balance more quickly and avoid side effects. I know that's a big "maybe", but I have seen fewer side effects on people begun at 10-20mg than those being reported here at 5mg. The population I observed was at a partial hospitalization program with 100-150 patients.
- Scott
poster:SLS
thread:864904
URL: http://www.dr-bob.org/babble/20081123/msgs/864984.html