Posted by Larry Hoover on November 22, 2008, at 9:58:48
In reply to kynurenic acid, posted by mike1975 on November 20, 2008, at 16:07:32
> Hi everyone,
>
> Could anybody give me more backgroung into kynurenic acid? How do you lower it?
>
> Thank you
>
> MikeKynurenic acid is a metabolite of tryptophan, but it's unconnected to the serotonin/melatonin sequence, or the one that leads to NADH.
High levels of it have been associated with schizophrenia, for example, but it's far from clear just what the association might be: the result of, the cause of, or both caused by the same underlying metabolic defect.
Kynurenic acid tends to accumulate due to low activity at the enzyme (L-Kynurenine hydrolase) designed to process it. That enzyme requires P5P, or phosphated pyridoxine (activated vitamin B6). Assuming no genetic defect, the solution lies with the vitamin.
So, there are two possible precipitating situations. The first is simply poor diet/poor B6 intake. However, even an adequate diet would be problematic if the individual had problems with converting pyridoxine to its active phosphated form. So, the most reliable solution would be to take P5P (pyridoxal 5-phosphate). If you do choose that route, take a B-complex vitamin as well, because vitamin B deficiencies have complex interactions amongst themselves.
Regards,
Lar
poster:Larry Hoover
thread:864254
URL: http://www.dr-bob.org/babble/20081114/msgs/864614.html