Posted by desolationrower on November 21, 2008, at 23:50:54
In reply to New anti-epilepsy drug, posted by mike1975 on November 21, 2008, at 8:22:30
hm, i can't seen to find much about how it works.
This was the only useful info:
Rufinamide: pharmacology, clinical trials, and role in clinical practice
A. CHENG-HAKIMIAN 1 , G. D. ANDERSON 2 , J. W. MILLER 3
Rufinamide is a structurally novel compound with anticonvulsant activity that is undergoing evaluation through the European Medicines Agency and the American Food and Drug Administration. Its mechanism of action is thought to be inhibition of sodium-dependent action potentials in neurons, with possible membrane-stabilising effects. Absorption of the drug is significantly enhanced in the fed state. The drug is extensively metabolised by non-CYP450 systems with a half-life of 812 h. Most common adverse effects noted are somnolence, fatigue and tremor. Efficacy against partial seizures in adults and adolescents has been demonstrated in three randomised, placebo-controlled trials. Efficacy against seizures of LennoxGastaut syndrome, a severe, disabling childhood onset epilepsy syndrome, was shown in a single randomised, placebo-controlled trial. Efficacy against partial onset seizures in children has been suggested in an open-label trial. Should rufinamide become commercially available, reserving the drug as a second- or third-line agent should be considered.
I honestly don't know much about ion channels as i'd like. I don't think there has been any look into how this would work for mood disorders.-d/r
poster:desolationrower
thread:864387
URL: http://www.dr-bob.org/babble/20081114/msgs/864570.html