Posted by desolationrower on November 15, 2008, at 8:42:49
In reply to melatonin and 5-HT receptors; ADD, dysexecutive, posted by iforgotmypassword on November 14, 2008, at 2:30:56
> hi. i was wondering if melatonin being a 5-HT2a antagonist (i believe?) is essential to moderating things in that system beyond during sleep. does it regularly sensitize the brain in some necessary way? if so, in some people is this sensitization less effective? (my reasoning for theorizing that there is a type of sensitization effect is how we tend to develop tolerance to 5-HT2a agonists. i.e. an effect shown by he drug well after it is no longer significant in the blood, and even more than the well known agonists, melatonin has very short half life)
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> 5-HT2a is supposed to be involved in decision making, and i gather for executive function. it also seems to be important for dopaminergic function in the PFC. i have tried to express my case before, but my lack of ability in this area is why i rarely respond to threads i start, even though i do follow them. messages are very hard to make, unless i am "in someone else's tide." interaction with people provides artificial motivation, but it is not functional, tends to magnify congnitive issues, and otherwise aside from being wound up i do very little and live in complete squalor.
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> in any case so this is about melatonin. i spend very little time in the dark (i cannot sleep without significant light, actual lights not night lights, and i often require noise.)
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> i am wondering if i may lack adequate production of melatonin, and if that may be producing a lack of moderation that it provides. if it could be causing my completely blown executive function, and ridiculous clustering of parkinsonian and akathitic-hyperactive symptoms.
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> sorry i can't make this message any more suitable for posting, sorry if it is not easy to read.melatonin has no known affinity for non-melatonin (mt1, mt2, mt3) receptors. still, if you are sleeping with teh lights on i'd take a couple mg of melatonin to keep sleep cycle working properly.
-d/r
poster:desolationrower
thread:862980
URL: http://www.dr-bob.org/babble/20081114/msgs/863159.html