Posted by SLS on November 15, 2008, at 6:07:12
In reply to Re: Long Time Antidepressant Psycho Dabblers? » SLS, posted by FrequentFryer on November 15, 2008, at 0:24:26
Hi.
I think using a dopamine receptor agonist is a treatment with a rather low probability of success. It does not tend to make people feel very well for extended periods of time. I have seen it help initially, though. If you choose to try one of these compounds, stay away from cabergoline and pergolide. They act to damage heart valves (valvulopathy) via agonizing 5-HT2b receptors. Although there is still debate about how often this occurs at low dosages, if you have alternatives, I would try those first. Mirapex (pramipexole) might have the best chance of helping. Unlike bromocriptine, which is restricted to D2 receptor agonism in the striatum and related structures, pramipexole works to stimulate both D2 and D3 receptors in the limbic system. The limbic system is responsible for feelings of reward and elevated mood.
Since none of us have a crystal ball for fortune telling, I would not presume to issue a recommendation to avoid Mirapex or Requip due to a lack of efficacy. You might very well benefit from them to make them worth keeping in your treatment regime.
Good luck.
- Scott> Cheers for the input.
> It is a tough one, I am gonna stick with the Nardil @ 90 for now.
> Do you know if there is much difference between the popular Dopamine agonists? could you recommend one considering $ I would like to import Carbergoline (Im in Australia) but i'ts pretty expensive.
> Would Bromocriptine or I dunno Mirapex do pretty much the same thing for mood and sex do ya reckon?
>
> > You have a difficult decision to make. I really don't have any strong feelings as to what you should do. I would only add that Marplan is an effective MAOI whose side effects are milder than those of Nardil.
> >
> > If you go back to Effexor, perhaps you can try adding Wellbutrin and/or nortriptyline.
> >
> >
> > - Scott
>
>
poster:SLS
thread:862241
URL: http://www.dr-bob.org/babble/20081114/msgs/863149.html