Posted by yxibow on November 7, 2008, at 3:41:20
In reply to Re: Is anyone taking doxepin? » linkadge, posted by clipper40 on November 7, 2008, at 0:09:27
> What do you know about doxepin and genotoxicity? Does this apply to all tricyclics or just specifically to doxepin?
Well the Silenor (doxepin for sleep) study completed its genotoxic study for NDA.
I'm not quite sure where this is coming from -- yes there are studies of breast cancer -- in women, and I suppose if they are provable maybe those most prone to it might need to make a choice, of tricyclics.
But the choice between any antidepressant, feeling miserable, and suicide, I think far outweighs the costs of cancer, considering any substance that we ingest or breathe has a potential cancer cause.
What if it was the agent that made one most happy and eliminated the worst symptoms? Would the theoretical cancer risk many decades into the future as opposed to mortality from depression be worse?
I'm not suggesting someone ingest thalidomide but I think there are priorities. Each is to choose as they wish.
-- Jay
poster:yxibow
thread:859496
URL: http://www.dr-bob.org/babble/20081106/msgs/861260.html