Posted by Marty on October 22, 2008, at 21:10:05
In reply to I feel worse on prozac, posted by linkadge on October 13, 2008, at 13:57:22
> This stuff is garbage. I just feel numb and worthless.
---
How do you react on antipsychotics with some 5-HT2c antagonistic properties ?Modern scientific literature consider Prozac to be more of a 5-HT2c antagonist than an SSRI. That is, the antidepressant effect of Prozac is attributed more to those antagonistic properties than from the SRIs properties.
Your 5-HT2c upregulation reponse to your 5-HT2c antagonism may be grossly exegerated.. the aftermath being MORE 5-HT2c stimulation (agonism from serotonin) and even more because of increased synatic 5-HT concentration because of the SRI. This is pretty interesting...
Counterintuitively, that hypothesis would suggest that you are a good candidate for 5-HT2c antagonism, but a stronger one that could cover your over the top upregulation... if that's possible.
Also, Prozac or not, you may be so sensitive to 5-HT2c endogenous agonism that everything increasing 5-HT receptor activity (SRIs etc) would end up cause more trouble than good because of too much 5-HT2c agonism.
Ever tried Desyrel (Trazodone) ? If so, how did you feel a couple hours before your next dose ? mCPP, one of Trazodone metabolite, is a 5-HT2c Agonist and I'll be interested in how you felt on it. Even more interesting is if you could get some right now and see how you react to it while being on Prozac... you could learn something very worthy about your personal neurology. Something that you could actually use to tweak your cocktail. Agomelatine is already there.. and if what you need is very strong 5-HT2c antagonism WITHOUT increased serotoninergic activity AND decreased dopaminergic activity (also very important) .. than is could be the missing thing in your cocktail.
/\/\arty
poster:Marty
thread:857224
URL: http://www.dr-bob.org/babble/20081016/msgs/858856.html