Posted by uncouth on October 19, 2008, at 9:11:12
Hello,
I'm on 40mg of parnate, which has been moderately effective in reducing my depressive symptoms, but extremely effective in cutting out the suicidal thinking. I'm also taking 5mg abilify.I was wondering what the pros and cons are to adding a low-dose of selegiline to the mix. I was on emsam 9mg/12mg in the past, and found it to be way too activating and anxiety inducing, but similar to parnate in it's effectiveness...just a bit harsher.
I'm extremely impressed with selegiline's neuroprotective abilities, independent of it's MAO-B action, and I was thinking about adding 2.5mg of oral (pill form, not liquid form) of selegiline daily to the mix, for neuroprotection and added "help" for my dopaminergic neurons.
I'd also expect that the low dose of selegiline would shift some of the parnate's action more to MAO-A (e.g., if selegiline is helping out with MAO-B, then more parnate can work on MAO-A than otherwise).
Is this a safe mix? Has anyone tried it before? Are there any general issues about combining MAOIs, even at low doses, that could be problematic?
Are there any selegiline experts out there that can speak to whether a low dose like 2.5mg will even have any neuroprotective/neurogenesis effects at all? (e.g., is it even worth it).
I should note my sleep has been bad on abilify + parnate, but i'm hopin such a low dose of selegiline won't add to the sleep issues, but provide me with more energy during the day, while I work on the sleep issues independently.
Thanks for all the comments. I'm going to try this unless someone specifically says "DANGER!"
poster:uncouth
thread:858218
URL: http://www.dr-bob.org/babble/20081016/msgs/858218.html