Posted by azalea on October 8, 2008, at 15:10:49
In reply to azalea: How about Trileptal with Dexedrine?, posted by qbsbrown on October 8, 2008, at 15:00:19
Many of the anticonvulsants do cause cognitive impairment, especially in higher doses. I'm not too familiar with Trileptal, however a quick PubMed search of trileptal + stimulant brought up the study below. Looks promising!
Eur J Clin Pharmacol. 1993;44(6):529-33.
Memory and psychomotor effects of oxcarbazepine in healthy human volunteers.
Curran HV, Java R.
Department of Psychiatry, Institute of Psychiatry, UK.Cognitive and psychomotor impairments can be unwanted adverse effects of antiepileptic drugs. The present double-blind, cross-over study with healthy volunteers was designed to assess the effects of two doses of oxcarbazepine (OXCZ) (150 mg b.i.d.; 300 mg b.i.d.) and a placebo, each given over a two week period. Twelve subjects completed a battery of tests before and 4 h after morning doses on days 1, 8 and 15. Results of objective tests indicated that OXCZ improved performance on a focussed attention task and increased manual writing speed. Subjective ratings showed OXCZ increased feelings of altertness, clear-headedness and quickwittedness. OXCZ had no effect on the range of long-term memory processes assessed in this study. It is concluded that at the doses employed, OXCZ has a slightly stimulant effect on some aspects of psychomotor functioning.
> Would/does Trileptal affect the Dexedrine?
>
> Unfortunately as my history shows, after being on top of the world for a couple of days with dexedrine, depakote, and lexapro, the lexapro threw me in to a mixed episode. Then I think that having a mixed episode w/ a stimulant almost throws me in to psychosis.
>
> So that's it w/ antidepressants with me, although they make me so much more personable and social like my normal self.
>
> Any suggestions other than Lamictal or Lithium?
>
> If only these anticonvulsants didn't make me stupid and more depressed.
>
> HHMM. What to do.
>
> Brian
poster:azalea
thread:854600
URL: http://www.dr-bob.org/babble/20081006/msgs/856436.html