Posted by desolationrower on October 1, 2008, at 19:29:43
In reply to Re: SSRI, Hallucination, Ketamine, posted by Babak on October 1, 2008, at 18:55:03
You could probably get a similar effect using dextromethorphan, without the legal risks. However no studies showing it works. Of course, you can't take that with an ssri (i think it causes serotonin release. i know you can take it with an maoi, probably shouldn't with an ssri)
also, i think either an alpha2 agonist or a benzo is used to prevent (theoretical, unproven) toxicity. might be improtant if it works. i'd think you'd need to take it once a week or so to remain in remission. i don't know of a serotonin syndrome risk, although 5ht2 blockers, used to prevent it, could potentially worsen neurotoxcicity from nmda blockade. but thats all really theoretical. actually memantine which is an nmda blcoker amoung other things prevents serotonin syndrome, and i think it is mostly likely mediated by nmda.
this might be of interest as well
SEROTONERGIC/GLUTAMATERGIC INTERACTIONS: POTENTIATION OF PHENCYCLIDINE-INDUCED STIMULUS CONTROL BY CITALOPRAM
free fulltext:http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1224745
Fluoxetine prevents PCP- and MK801-induced HSP70 expression in injured limbic cortical neurons of rats.
Biol Psychiatry. 2000 May 1;47(9):836-41.
"BACKGROUND: N-Methyl-D-aspartate (NMDA) receptor antagonists, including phencyclidine (PCP) and dizocilpine (MK801), cause schizophrenialike psychosis in humans, and produce vacuolated neurons in the cingulate and retrosplenial cortices of the rat brain. Since psychotically depressed patients and schizophrenic depressed patients may require treatment with selective serotonin reuptake inhibitors (SSRIs), it is of interest to examine the relationship between SSRIs and NMDA antagonist neurotoxicity. METHODS: The neurotoxicity of PCP and MK801 was assessed using heat shock protein (HSP70) immunocytochemistry and HSP70 Western blots because HSP70 is expressed in the injured, vacuolated neurons. Female rats were given fluoxetine (0, 5, 10, and 20 mg/kg IP) followed 1 hour later by MK801 (1 mg/kg IP) or PCP (50 mg/kg IP). RESULTS: Pretreatment with fluoxetine (20 mg/kg IP) 1 hour before MK801 prevented the induction of HSP70 by MK801 in the cingulate and retrosplenial cortices. Pretreatment with fluoxetine (10 or 20 mg/kg IP) 1 hour before PCP also prevented the HSP70 induction by PCP. CONCLUSIONS: Fluoxetine prevents the neurotoxicity of NMDA receptor antagonists in rat brain."i imagine you'll be tripping balls, as the recreational dose is subanaesthetic dose. i don't know how much was used in the study though. good luck.
-d/r
poster:desolationrower
thread:854925
URL: http://www.dr-bob.org/babble/20080926/msgs/855161.html