Posted by Phillipa on September 23, 2008, at 20:22:18
In reply to Re: glycine + memantine, posted by Phillipa on September 23, 2008, at 20:14:33
OOps googled it and wiki says it's investigational for schizophrenia copied a bit. Love Phillipa
Clinical uses
See also: 5-HT3 antagonist
The 5-HT3 receptor antagonists are the primary drugs used to treat and prevent chemotherapy-induced nausea and vomiting (CINV). Many times they are given intravenously about 30 minutes before beginning therapy. Ondansetron is also effective in controlling post-operative (PONV) and post-radiation nausea and vomiting, and is a possible therapy for nausea and vomiting due to acute or chronic medical illness or acute gastroenteritis.Although it is highly effective, its high cost had limited its use to controlling PONV and CINV- although it is now available in cheaper generic forms. It is also used off-label to treat hyperemesis gravidarum in pregnant women, but there is no conclusive data available on its safety in pregnancy, especially during the first trimester. It is also often used to treat cyclic vomiting syndrome; although there have been no formal trials to confirm efficacy, case reports suggest it can be helpful in some cases. The drug is administered 13 times daily, depending on the severity of nausea and/or vomiting. The normal oral dose for adults and children over the age of 12, is 8 mg initially, followed by a second dose of 8 mg, eight hours later. The drug is then administered once every 12 hours, usually not for more than 2-3 days. Following oral administration, it takes about 1.52 hours to reach maximum plasma concentrations. This drug is removed from the body by the liver and kidneys.
The clinical effect of ondansetron (and other drugs from the same group) can be potentiated by combining it with dexamethasone.
[edit] Investigational[edit] Schizophrenia
A 2006 double-blind, randomized controlled trial indicated that ondansetron may have value in the treatment of schizophrenia, as an adjunct to haloperidol. The study found the combination to significantly improve negative schizophrenia symptoms, and people taking both drugs experienced fewer of the adverse effects commonly associated with haloperidol;[2] an earlier, smaller, open-label trial had found ondansetron to be useful in treating antipsychotic-induced tardive dyskinesia in people with schizophrenia, and the study patients also showed significant improvement in the disease's symptoms
poster:Phillipa
thread:850659
URL: http://www.dr-bob.org/babble/20080915/msgs/853699.html