Posted by bleauberry on September 8, 2008, at 21:24:56
In reply to Brief immediate responses to meds?? - Advice Pls, posted by Four Feathers on September 8, 2008, at 9:04:00
I experience the same brief responses as you. While your timeframe is about 7 days, mine is about 3.
My own theory...the genetic programming tells the receptors how to respond to what the med is doing. They've gotten good at it with practice. For example, take an ssri, feel an immediate improvement, followed by worsening. My body liked the serotonin. And it was probably needed. But the autoreceptors, the governors, said "hey, no way, that's not how much serotonin there is supposed to be, so you guys over there making serotonin, slow down, and you guys over here squirting out serotonin, turn those hoses off". The genes always try to revert back to baseline programming, even when they are wrong.
If that theory of mine is true, then the receptors have to be tricked. Receptor blockers of various kinds, ranging from buspar to pindolol to remeron to antipsychotics, can fool the governors/genes so that the primary med can work as desired.
A few scientific studies hint that a good rapid response indicates a higher likelihood of robust response later on. So while the initial good response fades, it should slowly over weeks creep back in a subtle slow fashion.
And you may need a higher dose.
And some would say this is a sign of bipolar instead of depression. I disagree with that one, but hey. No one even knows what bipolar is anyway. Just a word to fit a description of symptoms, but no clue what is causing it or why.
So, take your choice. Just some ideas to ponder.
poster:bleauberry
thread:850938
URL: http://www.dr-bob.org/babble/20080903/msgs/851098.html