Posted by yxibow on September 7, 2008, at 3:51:11
In reply to Is Abilify pretty safe concerning tardive dys?, posted by theo on September 4, 2008, at 19:46:42
> Compared to other newer antipsychotics?
> Compared to other newer antipsychotics?
All atypicals have been pretty much established to have a risk of up to 5% per year for an unknown point and varies by individual, affective disorder (greater) or non-affective (e.g. schizophrenia, lesser).
That being said Abilify has about a 10% or greater chance of EPS (temporary and manageable with other medications, another word for side effects, especially akathisia)
The only known AP to have a significant risk in this category at the moment from what I know is Risperdal (and I suppose Invega)
The strength of D2 (and this isn't quite scientific because Zyprexa does have a low Ki [higher intensity] at D2 but I don't know that it grabs intensly like Risperdal or typicals) is probably:Risperdal/Invega->Abilify, Geodon-> Zyprexa, Seroquel.
And if you include the intense management of Clozaril, there have been no proven significant cases of people who have not taken any APs before or have had little exposure -- in fact it has been shown to improve TD for those who have.
That being said the risk of TD could be extrapolated about 0.1% for Seroquel, 0.5% for Zyprexa (there was an actual British Journal of Psychiatry study I forget) and it goes up more greater for the others.
Its unknown of course for anybody and the benefits have to outweight the risks for taking any atypical.
That being said, dose is also an issue that may affect it -- the MED (minimum effective dose) is always regarded as the best.
-- tidings
Jay
poster:yxibow
thread:850398
URL: http://www.dr-bob.org/babble/20080903/msgs/850743.html