Posted by Larry Hoover on August 18, 2008, at 18:50:22
In reply to Re: Is Pristiq a real advance?, posted by med_empowered on August 17, 2008, at 18:52:53
> I don't personally think its anything special. When you take Effexor, your body creates Pristiq.
I think that's an over-simplified view. Extensive metabolizers of venlafaxine produce 8 times more O-desmethylvenlafaxine than do poor metabolizers. The ratio of N-desmethylvenlafaxine to O-desmethylvenlafaxine can vary by more than 16-fold, with the highest ratios in poor metabolizers. Side effects are seen to be proportional to N-DV, whereas benefits proportional to O-DV concentration. We're not all alike with respect to Effexor, but Pristiq levels the playing field for all.
Lar
poster:Larry Hoover
thread:846875
URL: http://www.dr-bob.org/babble/20080814/msgs/847072.html