Posted by Marty on August 7, 2008, at 19:33:00
In reply to Re: Fluoxetine = 5-HT2c Potent antagonist ? ..confused, posted by bleauberry on August 7, 2008, at 19:08:08
> Actually no, not agreed. While all ssris had sexual side effects with me, prozac was by a long shot the friendliest.
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I'm glad to hear that because Prozac is the only SSRI that I didn't try yet. Many people reported Prozac to be harsher than others while not being as bad as let say Paxil. That would be interesting to start a thread and make a poll in the kind of "What was your best and worst SSRI regarding sex ? and list which one you tried." .. are you aware of a thread on pbabble in the past doing just that ?
> 5ht2c antagonism blocks the effects of serotonin at that receptor, which is actually a good thing for sex, not a bad thing.
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Yes, I'm well aware of this. That's why I was confused since I thought Prozac was one of the worst regarding sex and since 5-HT2c antagonism is a good thing for sex then I wondered why it wasn't one of the best regarding sex. Now that you mention that you found Prozac to be easier than others I guess that explains my confusion.
> The potency as a 5ht2c antagonist is actually sex-friendly. Of course, the serotonin reuptake is powerful enough to over-ride much of it. Due to the 5ht2c antagonism, prozac has been called an atypical ssri.
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I was aware it was called an atypical SSRI but I never look into why it was considered atypical. Very interesting. Are you aware if it also antagonize 5-HT2a to a significant level ?> And to say in a generalized manner that the 5ht2c receptor is responsible for sexual side effects is extremely oversimplified. It just aint that simple. Lots of stuff going on.
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No doubt
/\/\arty
poster:Marty
thread:844424
URL: http://www.dr-bob.org/babble/20080805/msgs/844853.html