Posted by Crotale on August 4, 2008, at 0:00:52
In reply to Despiramine for ADD-can anything be combined w/it?, posted by TriedEveryDrug on August 2, 2008, at 18:28:45
> Anyway, ssris always helped me w/ anxiety and social issues, but there is a 2d6 interaction between ssris and desipramine (ssris inhibit 2d6, which breaks down desipramine).
The SSRIs, Zoloft, Celexa, and Lexapro don't inhibit CYP2D6 to as great an extent as do Prozac, Paxil, and Luvox. It's possible to use the combination, preferably with one of the SSRIs that have less of an effect on this enzyme. You should only do this under your doctor's supervision, of course; you would lower your dose of desipramine, and then get your serum level tested and gradually raise the dose, continuing to monitor your desipramine levels.
You might want to get your serum desipramine level checked anyway, as some people are poor metabolizers due to a genetic mutation.
> Anyway, has any other antidepressant been successfully combined with desipramine? I can't really take the side-effects, even at the lowest doses. Which sucks because it works so well :(
MAOIs such as Nardil and Parnate can be used in combination with desipramine, since it has hardly any effect on serotonin uptake.
A number of antidepressants can be used with caution in combination with desipramine, provided desipramine serum levels are monitored.
There are also other medications that might help you besides traditional antidepressants.
-Crotale
poster:Crotale
thread:843781
URL: http://www.dr-bob.org/babble/20080727/msgs/844036.html