Posted by yxibow on July 31, 2008, at 2:00:19
In reply to Re: Like Trazodone for sleep but w/o heart problems, posted by jrbecker76 on July 26, 2008, at 23:51:36
> > > So basically I'm looking for an anti-depressant with sedating properties like Trazodone but with no heart-related side-effects.
> > >
> > > Thanks
> >
> > The tricyclics doxepin, trimipramine, and amitriptyline are all used to promote sleep.
> >
> > Lar
> >
> >
>
> Nefazadone (Serzone) and Trazadone both metabolize into m-CPP, a serotonin agonist that causes a host of side effects, including chest pressure and heart palpitations. For most, the adverse events typically subside after initial titration and/or can be controlled by reducing your daily dosage. However, they can be a continual problem for some.
>
> There is a new hypnotic class of 5-HT2 antagonists that will be on the market soon that will provide many of the benefits of nefazodone and trazadone, but with less of a side effect profile. Eplivanserin, which is a drug candidate from Sanofi-Aventis, should reach the market sometime next year. In the meantime, I would add to the other posters' recommendations by also throwing out there Rozerem (ramelteon). Some people find it does nothing, but many others report it gives them a great night's sleep with little residual effects in comparison to the GABA-A class of hypnotics (Ambien, Sonata, Lunesta). I take Rozerem in combination with a very low-dose of Nefazadone nightly.
>
> JB
As for whether anything from France politically ever makes it past the FDA, we shall see -- there have been diminishing returns from companies like Servier (just an observation).m-CPP can cause those effects I suppose, yes, I did have an idosyncratic but self-limiting palpitation with Trazodone. But primarily m-CPP presents a problem with people prone to its effects on psychosis. Its not the best choice.
poster:yxibow
thread:842117
URL: http://www.dr-bob.org/babble/20080727/msgs/843197.html