Posted by linkadge on July 30, 2008, at 16:55:35
In reply to Re: Atypical Antipsychotic Augmentation Theories? » med_empowered, posted by Bob on July 30, 2008, at 14:30:49
Typical antipsychotics are used to produce certain models of depression.
It is theorized that certain antidepressants achieve their final target by enhanced responsiveness of d2/d3 receptors. Antipsychotics with potent d2/d3 blockade are appear to block the effect of many antidepressant compounds.
Antipsychotics with high 5-ht receptor occupancy in comparison to dopamine receptor occupancy may produce less depression owing to the ability of 5-ht receptor blockade to enhance dopaminergic neurotranssmission in certain brain regions.
Perphenazine is kind of an atypical in that it does have moderate inhibitory binding at 5-ht receptors.
I think that the more selective a drug is for postsynpatic dopamine receptors the more likely it is to produce depression, unless the depression is extremely agitated or psychotic or something.
Linkadge
poster:linkadge
thread:842918
URL: http://www.dr-bob.org/babble/20080727/msgs/843095.html