Posted by Quintal on July 24, 2008, at 7:18:49
In reply to Re: Where to go with Morphine?, posted by okydoky on July 23, 2008, at 18:17:51
That's why I asked, most sources have a blanket statement saying all opiates are contraindicated with MAOIs, but this isn't true - only a few select ones are, and that's because they happen to have additional serotonin reuptake activity and this carries the risk of serotonin syndrome. Pethidine, tramadol and dextromethorphan are the main culprits if I remember rightly. Morphine, oxycontin, codeine, buprenorphie and methadone are okay, but most patient resorces will state otherwise. I remember my pdoc saying when I started Parnate "If you get run over by a bus there will be nothing we can give you" (!).
The pharmacologist Ken Gillman has published some excellent advice on MAOI-opiate interactions:
http://www.psychotropical.com/8_st_maois_opiate_analgesics.shtmlA few posters on babble have combined buprenorphine and codeine with Parnate in the past, so you might want to check the archives. I think Elizabeth was one of the most prominent.
Q
poster:Quintal
thread:841597
URL: http://www.dr-bob.org/babble/20080718/msgs/841753.html