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Re: Cheat's Parnate) Moclobemide + Selegiline ?

Posted by Astounder on July 16, 2008, at 2:08:52

In reply to Cheat's Parnate) Moclobemide + Selegiline ?, posted by West on July 14, 2008, at 18:07:03

Wellbutrin is safe with MAOIs. It does not cause the serotonin syndrome and pretreatment in fact will dose-dependently abolish the tyramine pressor response (by blocking tyramine uptake) while also attenuating the orthostatic side-effects of MAOIs (by blocking octopamine uptake and NE reuptake). MAO-A inhibitor + MAO-B inhibitor + DA/NE reuptake inhibitor (Wellbutrin) is pretty much all Parnate is.

I'd up the moclobemide + selegiline until you're limited by the side-effects, then up the Wellbutrin until the side-effects go away. If you reach 1200 mg without alleviation, try adding on a 5-HT2A antagonist like low-dose Risperdal (0.5 mg) or high dose Remeron (45-90 mg) before you abandon MAOIs completely.


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URL: http://www.dr-bob.org/babble/20080706/msgs/839950.html