Posted by satsumas on July 14, 2008, at 12:52:56
Hi,
Does anyone have any experience with Effexor, Desipramine, and Nardil (not all at the same time). I'm currently on 100mg of desipramine after tapering off of 300 of Effexor the past month. Effexor at that high level was the only time I have really felt "good" in the past year, unfortunately, it had some side effects that were troubling (food/nicotine/alcohol/internet compulsions) and put me on the edge of hypomania. When I've taken Effexor in the past, I've noticed that it either has to be working at 100%, and i'm at the edge, but not over the edge, to hypomania, otherwise it's almost worse than no a/d, since when it's at 70% effective, all I get is the side effects of apathy, amotivation, anhedonia, and the compulsions, but mood isn't high enough to offset it and I end up just blahing through life.After realizing this is what I was doing for a long time (it took a suicidal depressive episode to see this clearly) I knew I had to change things. We're now trying desipramine, a highly NE selective TCA, but after being at 100mg for the past two weeks, i'm feeling extremely blah. I know it's a relatively low dose, but even at this point, i'm getting some bad side effects, and i'm not sure if I want to spend another month tapering up, trying to find the right dose to see if this will work.
I think at this point, given a partial response to Emsam I had earlier this year, I want to bite the bullet and try Nardil.
I'm interested in hearing from those who have taken Nardil, Effexor, and/or Desipramine speak about the subjective experience on either drug...especially in regards to effectiveness, any emotional blunting effects, and side effects between the three (especially Nardil vs. Effexor).
Thank you so much. Pdoc appt. tomorrow and want to be able to have some good insight into whatmakes sense at this point, given that i'm in a bit of a crisis and don't have time to waste on trials -- i need something to get me out of this pit ASAP :(
poster:satsumas
thread:839669
URL: http://www.dr-bob.org/babble/20080706/msgs/839669.html