Posted by yxibow on July 13, 2008, at 1:02:24
In reply to Re: DEPLIN L-methylfolate, posted by Cobra on July 11, 2008, at 11:31:04
> No history of CVD or miscarriage does not mean you for sure don't have a MTHFR polymorphism. Depending on the specific polymorphism your parents may each be heterozygous (a milder polymorphism resulting in only slightly decreased enzyme function) and could each have given you the "bad" copy making you homozygous for the polymorphism and therefore more susceptible to the myriad of complications.
>
> The only way to know for sure is to have a genetic test done. Many times the cheek scrape test is covered by insurance, and also can include other genes.
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> My personal feeling is that since 50% of people are going to have a version of the polymorphism and since the consequences are devastating in terms of both physical and mental health that taking some sort of l-methylfolate supplement is just a safe bet. Your body will use it, even if you live a 100% healthy lifestyle and do not have the polymorphism. But that is just my personalIt isn't used widely in tests since a number of people, unknown, will have some, version of the polymorphism, however not much to affect any human function.
> Deplin is only FDA approved for enhancing the efficacy of anti-depressants and managing plasma folate, but in terms of those patients with MTHFR polymorphism it can do much more.
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> Hopefully in the near future genetic screening will become a part of all primary care physicians' routine patient care. The cost continues to drop, and for a huge percentage of the population it would mean a vast improvement in the quality of care.
>
> So it's really up to you for the Deplin- it is extremely likely that it will help you. And from all the studies I've read there is really no drawback other than the cost of the supplement.
Unfortunately it is fairly likely that it -wont- help someone. But you could be one of the lucky crowd that it does. Its more of a winning a lottery than actually being a large number. But for those who do benefit, it apparently definitely does.
And there are drawbacks, anxiety related -- now, I don't know if I tried it for several months whether it would be of help, but it exacerbated my anxiety, and in my case my anxiety, being somatoform, is expressed in bodily manners.
My blood pressure would skyrocket in pangs especially when I was getting to get out the door and behind the wheel of my car. This was only after two weeks, and two weeks without it, it went away. I had to use propranolol at various points as I was running a good 150-160/90.
poster:yxibow
thread:803728
URL: http://www.dr-bob.org/babble/20080706/msgs/839510.html