Posted by bulldog2 on July 11, 2008, at 16:17:32
In reply to Cymbalta + liver damage, posted by Jamal Spelling on July 11, 2008, at 15:54:55
> I don't know whether to carry on with Cymbalta. I'm scared I'll get liver damage. Can anyone quantify this risk for me? I don't drink at all, and I use no medications other than Cymbalta.
>
> I seem to be doing well on Cymbalta. I might even say it is the most effective AD I've ever taken.
>
> Even the FDA patient information sheet warns of liver damage:
>
> http://www.fda.gov/cder/drug/InfoSheets/patient/duloxetinePIS.pdf
>
> I've done some reading on PubMed, but I cannot find anything definitive. Some studies conclude "Cymbalta is a safe and effective antidepressant.". But then the list of authors reads something like "P. Smith, M.D., Eli Lilly Research Laboratories".
>
> It seems on average that articles published by researchers not affiliated with Eli Lilly are less favorable to the drug. Then you get conclusions like "There is insufficient evidence to support the use of duloxetine for the treatment of peripheral neuropathy.".
>
> I starting tapering off a few days ago. I'm now on about 45 mg per day, give or take.
>
> So far I feel more emotional. I feel like crying a lot. I also feel more pessimistic. But I do not feel depressed.
>
> I've been sleeping a lot more since I began reducing the dose. I also wake up feeling less refreshed.
>
> I've also had some moments where I have felt dizzy and depersonalized.
>
> OTOH I've also starting exercising again.
>
> Any thoughts? Does anybody know the actual risk of liver damage in taking Cymbalta?use sam-e...it'll protect you from liver damage while on the med.
poster:bulldog2
thread:839286
URL: http://www.dr-bob.org/babble/20080706/msgs/839290.html