Posted by SLS on July 4, 2008, at 15:45:34
In reply to Re: +++ MAO-A or B ? Gerovital (procaine) selectivity, posted by undopaminergic on July 4, 2008, at 13:36:27
> Clorgyline, similarly to selgiline, is subtype selective in low doses.
I am not aware of a loss of selectivity at any dose. It is not like selegiline in this regard. It is specific (not selective) to MAO-A. I would not yet presume additional mechanisms of action contributing to its antidepressant efficacy. Clorgyline is the most reliable probe specific to MAO-A and is the standard of reference by which MAO-A is assayed.
- Scott
poster:SLS
thread:836966
URL: http://www.dr-bob.org/babble/20080626/msgs/838038.html