Posted by undopaminergic on June 25, 2008, at 2:59:58
In reply to Opiates, oxycodone, posted by cactus on June 22, 2008, at 4:07:10
Buprenorphine rarely produces a high (never, in my experience - not even with stimulants), and may have a reduced tendency for inducing tolerance. Moreover, it's a kappa-opioid receptor antagonist, which reduces the incidence of many unpleasant effects. It also has a milder withdrawal syndrome than other opiates.
Combining opioids with NMDA-antagonists is a useful strategy for preventing or at least attenuating tolerance. The most useful options for NMDA-antagonists are memantine and dextromethorphan; amantadine might be an option.
Opioid rotation strategies may also be effective in the long run. In short, because cross-tolerance is often incomplete, switching to a different opioid drug may restore efficacy as one is failing.
poster:undopaminergic
thread:835899
URL: http://www.dr-bob.org/babble/20080617/msgs/836344.html