Posted by dcruik518 on June 21, 2008, at 18:41:48
In reply to Didn't like Requip, posted by Dopamine123 on June 20, 2008, at 21:08:49
> I tried requip which has the same mechanism of action as mirapex. I found the cognitive side effects to be really bad. Requip tends to cause executive dysfunction because of reduced stimulation of the d1 receptors in the prefrontal cortex. The D2/D3 receptors are stimulated by the drug, but this actually reduces the amount of real dopamine in the synapse leading to a decreased activation of d1 receptors.
>
> So my verbal fluency (ability to talk) and concentrate took a huge hit when on the drug.
>
> My blog:
> http://brainstimulant.blogspot.comHi,
I'm taken requip and bromocriptine and have noticed something similar, I think. If I take a lot I get drowzy and a bit dopey, similar to taking too many benzos. this wasn't the case, however, when first started taking either one, though, so somehting must change in the brain's reaction to the med or perhaps it builds up the blood.
What I've found works well is to just take small amounts a bedtime and once during the day. I also take Adderall which I suspect stimulate the D1 receptor and the frontal lobes in general.
DRC
poster:dcruik518
thread:834964
URL: http://www.dr-bob.org/babble/20080617/msgs/835843.html