Posted by dcruik518 on June 18, 2008, at 18:19:26
In reply to Re: Trazadone is perfectly safe with Emsam!!, posted by SLS on June 18, 2008, at 4:57:59
I don't understand this very well, but my doctor mentioned and recently read something interesting about why certain people may be more susceptible to serotonin syndrome. There is a genetic liver abnormality in about 7% of caucasians, an inability to properly metabolize drugs of the cyp450 class, I believe, and this leads sometimes to blood levels of up to 30 times what one would normally expect.
Also, according Stahl, the MAOI + Trazadone combo should only be done under close supervision by a very experienced p-doc.
For me though, it was never ever a problem, even taking 300 mg trazadone at night and 90mg of Nardil in the day.
~DRC
poster:dcruik518
thread:826808
URL: http://www.dr-bob.org/babble/20080617/msgs/835329.html