Posted by dbc on June 6, 2008, at 12:04:48
In reply to Re: Ritalin (methylphenidate) vs Dextroamphetamine, posted by undopaminergic on June 6, 2008, at 11:16:34
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> You may find the "coming down" from MPH unpleasant, but wait till you see that of DXP, and all your adverse experiences with MPH will seem exceedingly benign. Remember the storage vesicles that were emptied by DXP? They have to be refilled, and during the time it takes for that process to complete, you will essentially be dopaminergically deficient. To add insult to injury, this refractory period of neurotransmitter replenishment is in addition to the downregulation of receptor density or sensitivity that also occurs with MPH, but that is much more severe with DXP due to its greater potency.
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Woooah there, this is quite the opposite. The crash from MPH for most people is a sudden hard crash which is extremely abrasive much like its bigger brother cocaine and people often find themselves desiring to stay at a certain level MPH use to avoid this. Dexedrine on the other hand while rewarding at first doesnt like repeated dosing or you experiance some sort of autoreceptor feedback and the only way to fix it is to escalate the dose and if you're sane you will not do this.There is a much higher rate of potential abuse with dexedrine BUT to say anyone who uses it is going to become horribly strung out and addicted like a junkie is silly and we know its untrue. Theres a perfectly well adjusted subsection of people that have been using the drug for years without escalating doses and abusing it.
In the long run the racemic mixtures of amphetamine are more dangerous simply due to the nature of the L-AMP and im pretty certain thats pretty agreed upon.
In all honesty MPH was extremely grating and abrasive of a stimulant and made me think of its bigger uglier brother. While dexedrine was a positive experiance as long as i kept to my normal doseage.
poster:dbc
thread:833197
URL: http://www.dr-bob.org/babble/20080606/msgs/833299.html