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Re: Do mood stabilisers block antidepressants?

Posted by linkadge on June 3, 2008, at 10:05:59

In reply to Re: Do mood stabilisers block antidepressants?, posted by maz81 on June 2, 2008, at 13:32:14

Sometimes its hard to demonstrate that antidepressants even work at all. So the fact that one study suggests the addition of an AD to a mood stabilizer doesn't do anything doesn't necessarily conclude that the mood stabilizer is blocking the AD effect.

The ratio of successful studies for bipolar depression compared to unsuccessful ones is not good. There is very little data at all to suggest that lamotrigine is good for bipolar depression. Even if you go to the GSK clinical trial registry there is a sparsity of failed clinical trials of lamotrigine for BP depression and only one or two successful ones (even then it was not successful on primary measures).

Linkadge


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