Posted by Amigan on May 30, 2008, at 9:35:39
Hi.
My doctor prescribed me Clorazepate (Tranxene) probably because it has lower abuse potential from most benzodiazepines.
I read that from all benzos, Clorazepate is the only one that has unstable absorption from the digestive track. This is because Clorazepate itself is, in fact, inactive and it needs to be converted to NorDiazepam which is psychoactive.
The Clorazepate -> NorDiazepam conversion needs the presence of stomach acid (HCl). If you ingest an anti-acidic med like Maalox or something, Tranxene will hence become ineffective.
So, what i need to ask is:- Is the HCl acid itself what reacts with Clorazepate to convert it into NorDiazepam, or it just acts as a Ph-adjustment for some other enzymes to do the conversion?
- If the acid is indeed does the conversion, what will happen if i dissolve Clorazepate into an organic acid like citric acid? (aka lemon juice) Will it react to produce NorDiazepam?
poster:Amigan
thread:832058
URL: http://www.dr-bob.org/babble/20080528/msgs/832058.html