Posted by undopaminergic on May 28, 2008, at 23:02:13
In reply to Re: C*A*F*F*E*I*N*E..as an antidepressant?, posted by linkadge on May 28, 2008, at 21:21:34
> >That is because caffeine is a poor stimulant of
> >mesolimbic dopamine.
>
> True, but the beta carbolines may have some effect there. Regardless, a drug doesn't need to directly enhance mesolimbic dopamine to be an effective AD.
>My comment addressed the issues of why caffeine is "not much of a euphoriant" and why "Animals do not self inject caffiene like they do cocaine". No-one has claimed that an antidepressant needs to enhance mesolimbic dopamine. Furthermore, you may wish to make up your mind as to whether we're discussing caffeine or beta-carbolines, as they are not equivalent.
> I personally don't get over fixated on the suposed effects of dopaminergics. Dopamine is not the magic pleasure chemical.
>You are wise not to get fixated on supposed effects, but I wonder how magic pleasure chemicals are relevant to the topic at hand.
poster:undopaminergic
thread:831456
URL: http://www.dr-bob.org/babble/20080528/msgs/831812.html