Posted by linkadge on May 28, 2008, at 20:15:39
In reply to Re: The best Tricyclic for anxiety.... » linkadge, posted by torachan on May 28, 2008, at 19:24:10
>I assume due to the noradrenergic effect, but >doesn't Effexor only affect norepinephrine at >around 225 mg? And you said a serotonin agonist >would go well with a serotonin blocker, so >perhaps Effexor at around 75-150mgs with Remeron >at say 15-30mgs may be a good combo for anxiety?
Yes and no. Some people say that remeron reduces the anxiogenic effect effexor but it may increase it via a different mechanism.
Remeron increase norepinephrine release via a mechanism destinct of that of effexor. The combination has been called "California Rocket Fuel". It can apparently be very stimulating in high doses.
I did not do well on remeron plus effexor (major high blood pressure and anxiety) but did very well on a citalopram / remeron combination.
In this case, the 5-ht antagonism may reduce certain forms of anxiety, but the added NE effect may cause a different form of anxiety.
Effexor may do well in combination with low dose trimipramine, doxapin, or amitryptaline.
Some people do well with effexor and low dose seroquel.
There is some evidence that the combination works synergistically to reduce the neurological effects of chronic stress.
see:
I used cyproheptadine in combination with effexor with sucess. I don't know if you can get your hands on cyproheptadine.
Linkadge
poster:linkadge
thread:831465
URL: http://www.dr-bob.org/babble/20080528/msgs/831765.html