Posted by undopaminergic on May 15, 2008, at 15:54:38
In reply to Re: Is amineptine (survector) totally extinct?, posted by okydoky on May 12, 2008, at 9:31:12
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> > > I connot take tianeptine.
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> > Why not?
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> > Abilify may augment, or it may antagonise. Amisulpride or sulpiride, at low doses, would presumably augment or do nothing, so I would try those first (they may augment Ritalin too). Selegiline and rasagiline may also be of interest as additions. Last, but not least, memantine has in several cases been effective in preventing tolerance to stimulants, but in my experience it's more useful than that, and it's certainly worthy of consideration for almost anyone who responds well to stimulants - or amineptine.
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> > Did you try anything with serotonin 5-HT2A-receptor antagonism? Cyproheptadine (Periactin) has that property in addition to being a sedating antihistamine. If required, combining such an agent with a benzodiazepine or Z-drug would be possible.
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> Firstly I cannot take a lot of drugs because of a preexisting bladder disease called Interstitial Cystitis.
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> I do not quite understand "antagonise" could you explain simply?
>I meant that aripiprazole (Abilify) may reduce the effectiveness of the amineptine - this is a definite risk, but some people find Abilify energising, and it's also possible that it would work well in combination with amineptine. Only by testing it in the individual case can the outcome be determined.
> Amisulpride caused prolactin problems in the past. I had to discontinue.
>Prolactin problems? Like sexual dysfunction and galactorrhoea?
> Not sure about Selegiline or rasagiline but someone else said they had taken it with amineptine. Will consider. With consideration to my cognitive impairment this looks attractive. Which one?
>Selegiline is cheaper; it also differs from rasagiline in that its extensively metabolised into several pharmacologally active substances, including amphetamines; also in contrast to rasagiline, selegiline has affinity to the alpha2B-adrenergic receptor. You'll have to decide for yourself whether any of that is of significance.
poster:undopaminergic
thread:827088
URL: http://www.dr-bob.org/babble/20080510/msgs/829273.html