Posted by Larry Hoover on May 11, 2008, at 20:27:48
....which can be associated with suicide later in life.
http://www.plosone.org/article/fetchArticle.action?articleURI=info:doi/10.1371/journal.pone.0002085
Here are some quotes lifted from the text of the study:
"In the present study, we tested the hypothesis that rRNA in the human hippocampus of suicide subjects with a history of childhood abuse or severe neglect and controls who died suddenly of unrelated causes without a history of childhood abuse or severe neglect is differentially methylated and expressed....
The rRNA promoter was heavily methylated throughout the promoter and 5′ regulatory region in the hippocampus of suicide subjects in comparison with that of controls (F(1) = 191.04, P<0.0001). Twenty-one out of 26 CpG sites were significantly more methylated in suicide subjects compared to controls, whereas no CpG was more methylated in controls relative to suicide subjects (F(25) = 11.01, P<0.001)....
A greater number of sequenced clones were hypermethylated in the suicide subjects, whereas control subjects showed a greater number of hypomethylated clones. An analysis of the regression slopes between groups revealed a significant (F(1) = 7.33, P<0.01) interaction between the number of methylated CpG sites per clone for suicide subjects compared to controls. These data indicate a dramatic increase in the ratio of methylated to unmethylated clones among suicide subjects across most CpG sites....
There were no significant differences within the suicide subjects or the controls when the overall percentages of rRNA methylation of those with mood disorders were compared to those without mood disorders as well as among those with substance abuse disorders compared to those without substance abuse disorders (all P's>0.05)......
Lar
poster:Larry Hoover
thread:828589
URL: http://www.dr-bob.org/babble/20080510/msgs/828589.html