Posted by Ron Hill on May 11, 2008, at 18:08:09
In reply to Re: Deplin Blood Levels » Ron Hill, posted by Bob on May 11, 2008, at 13:11:41
>> http://www.ajcn.org/cgi/content/full/84/1/156#F1
--------> Not sure I completely understand the charts, but seems like it shows the concentrations steadily increasing over the weeks.
That's my take on it. For a constant dosage of Deplin, the plasma and red blood cell folate concentrations continually increase over the 24 week time period presented. I find it interesting that Deplin takes so long to reach steady-state conditions. It's a moving target if a pt is trying to determine his/her optimal daily dosage. Over the 24 weeks presented, the longer the pt takes a constant daily dosage, the more "potent" the dosage becomes.
> Can I assume that it might take about the same amount of time for the med to be metabolized out?
No. Here are some links that provide the type of information you are looking for:
1) See page 6 of this pdf document: http://www.metafolin.com/pdfs/Scientific_Review_13.12.pdf
2) See Figure 4 on page 10, and Table 2 on page 11 in the following document. PteGlu is folic acid and 5-CH3-H4PteGlu is L-methylfolate: http://www.metafolin.com/pdfs/Submission%20Letter%20Merck%20(Attachment%20II).pdf
Note: Both of the above documents are on the Metafolin website. Merck owns the patent on the process used to make L-methylfolate and the trademarked name is Metafolin. The L-methylfolate in Deplin, CerefolinNAC, Metanx, and the OTC's are all Metafolin.
Here is the URL for the Metafolin site. Click through the links on the home page. Lots of good information above and beyond what I have sited above. Don't overlook the Product Registration links. http://www.metafolin.com/
3) Scroll down to the bottom of this page on the Deplin site: http://www.deplin.com/HealthcareProfessionals,Deplin
4) Notice that Reference 17 is cited as the origin of these data on the Deplin site. Here is a link to Reference 17. It's a clean site (Nature), so it's safe to download: http://www.nature.com/bjp/journal/v141/n5/pdf/0705446a.pdf
-- Ron
poster:Ron Hill
thread:828002
URL: http://www.dr-bob.org/babble/20080510/msgs/828564.html