Posted by undopaminergic on April 29, 2008, at 4:24:27
In reply to Waking at 2am : Sonata or Ambien, posted by 4WD on April 28, 2008, at 5:47:40
Sonata may be the best one to take upon waking in the middle of the night, but it would probably be rather useless to take at bedtime due to its short duration of aciton.
Ambien is a good choice for administration at bedtime.
However, I would consider the antihistamine cyproheptadine (Periactin) first, as it's also a serotonin 5-HT2-receptor antagonist, and serotonin is likely to be involved in the pathophysiology underlying MAOI-induced insomnia. Furthermore, EEG studies suggest that cyproheptadine improves sleep quality, whereas other antihistamines are neutral, and benzodiazepines are detrimental. Sonata and Ambien are most similar to benzodiazepines in their actions, and may share similar effects on sleep quality.
poster:undopaminergic
thread:825989
URL: http://www.dr-bob.org/babble/20080420/msgs/826205.html