Posted by Amigan on April 20, 2008, at 18:50:18
In reply to how do SSRIs cause EPS, akathisia, perm. damage?, posted by iforgotmypassword on April 18, 2008, at 20:16:04
> wondering how SSRIs cause this harm.
Excessive serotonin in the synaptic cleft binds to certain 5-ht receptors and this causes a drop in the release of dopamine.
An indirect decrease of dopamine caused by serotoninergic drugs.> i have been afraid of anything serotonergic for years. i still have permanent EPS, rigidity, akathisia, and twitches.
"permanent EPS" sounds like tardive dyskenisia. It is caused by antipsychotics mainly, not antidepressants.
ADs can cause akathisia and EPS to sensitive people but not permanently, afaik.
Are you sure that you haven't been taking any APs?
Have you ever experienced serotonin syndrome?
Have you ever combined SSRI with contradicted, illicit drugs?> i may have had a predisposition,
Most probable.
> but this has happened to other people too. what is the mechanism?
I can't remember reading a case of TD caused by SSRIs alone. It must be a very rare thing.
> should i continue to consider drugs that are serotonergic as off-my-list?
I can't answer that.
poster:Amigan
thread:824139
URL: http://www.dr-bob.org/babble/20080420/msgs/824461.html