Posted by bleauberry on April 15, 2008, at 18:59:32
In reply to Okay, kinda a dumb question..........., posted by Happyflower on April 14, 2008, at 20:45:01
My experience is the same as already described. Slowly over 2 to 3 months things gradually changed, but I wasn't aware of them changing because they crept in very subtly. It became normal for me to really get into talk radio, visit nurseries and dream of the plants I wanted to grow, plan all kinds of projects, do very well at work, and such. But I wasn't outgoing, happy go lucky, bouncy, or anything like that. I had just inched back into life and didn't realize it until looking backwards.
While clinical studies usually go 6 to 8 weeks, sometimes 12, I really think the greatest benefits don't sink into until starting at 12 weeks. In other words, I think for someone who got a partial response by 12 weeks, many of them were on track for a full response by 24 weeks. That happened to me on Paxil. It took forever, but it worked. With other drugs I was too impatient and ended up augmenting with other things to try to speed it up or get specific desired effects (remeron/sleep; adrafinil/vigilance; zyprexa/sleep and overall augmentation...just some examples).
Clearly though if there is no benefit at all by 6 weeks, that is not a promising sign. If none by 8 weeks or 10 weeks, I think it is time to change. But if there is some noticeable improvement you can point your finger at, it is probably worth another month or three to see.
poster:bleauberry
thread:823332
URL: http://www.dr-bob.org/babble/20080412/msgs/823484.html