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Serotonin syndrome

Posted by kaleidoscope on April 12, 2008, at 12:39:00

In reply to serotonin syndrome, posted by David F on April 12, 2008, at 11:55:17

Hi

Linezolid is a reversible, non-selective monoamine oxidase inhibitor (MAOI). Linezolid should not be given in combination with SSRIs such as paroxetine unless close medical observation/monitoring is available (in hospital) - even then, it should only be used with paroxetine if no alternative antibiotic is available and paroxetine cannot be stopped. Serotonin syndrome is indeed possible.

Is linezolid being used to treat MRSA? If so, there are normally alternative antibiotics (some oral, some IV) which can be used.... depending on the site of infection and the results of sensitivity testing. In some places, such as the UK, community-acquired MRSA infections are normally sensitive to quite a variety of antibiotics. The situation is worse in the US, where antibiotic resistance is more widespread.

K



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URL: http://www.dr-bob.org/babble/20080412/msgs/822866.html